ISSN 1662-4009 (online)

ey0020.12-13 | Food for Thought | ESPEYB20

12.13. The artificial sweetener erythritol and cardiovascular event risk

M Witkowski , I Nemet , H Alamri , J Wilcox , N Gupta , N Nimer , A Haghikia , XS Li , Y Wu , PP Saha , I Demuth , M Konig , E Steinhagen-Thiessen , T Cajka , O Fiehn , U Landmesser , WHW Tang , SL Hazen

Brief summary: This observational study in three different cohorts found an increased risk for atherothrombotic disease associated with the commonly used sugar substitute erythritol. Untargeted metabolomics (in cohort 1, n=1157) and targeted metabolomics (in cohorts 2 and 3, n=2149 USA and n=833 Europe, respectively) investigations revealed an increased risk for major adverse cardiovascular events (MACE) including death, myocardial infarction and str...